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KMID : 0043320010240010035
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Archives of Pharmacal Research
2001 Volume.24 No. 1 p.35 ~ p.38
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Naphthazarin Derivatives (Vil): Antitumor Action against ICR Mice Bearing Ascitic S-180 Cells
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Song GY
Kim Y/You YJ/Cho H/Ahn BZ
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Abstract
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Various analogues of 5,8-dimethoxy-1,4-naphthoquinone (DMNQ) such as 2-or6-(I-hydro- xyiminoalkyl)-DMNQs were prepared and evaluated for the antitumor action.(1-hdroxyimi- noalkyl)-DMNQ derivatives expressed greater antitumor action than (1-hydroxyalkyl)- or acyl-DMNQ derivatives. Moreover, 6-(l-hydroxyiminoalkyl)-DMNQ derivatives expressed higher antitumor action than 2-sudstituted ones, suggestive of a steric effect. Some of 6-(I-propyloxyalkyl)-DMNQ derivatives with an alkyl group of butyl to octyl moiety showed T/C values of >400%
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KEYWORD
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